Is olanzapine safe in pregnancy?

Can olanzapine cause miscarriage?

Miscarriage can occur in any pregnancy. Most studies have found that the chance of miscarriages, when taking olanzapine, is similar to that of women taking similar medications. Also, studies have shown that untreated or poorly-treated depression itself may increase the chance for miscarriage.

What pregnancy category is olanzapine?

Safety of Psychiatric Medications During Pregnancy and Lactation

Drug FDA pregnancy category*
Haloperidol (Haldol) C
Loxapine (Loxitane) C
Olanzapine (Zyprexa) C
Perphenazine (Trilafon)‡ C

Which antipsychotics are safe in pregnancy?

There is no good evidence that any one antipsychotic is the safest to use in pregnancy. However, one large study, which found no increased risk of birth defects for antipsychotics in general, did show a small increased risk with Risperidone4.

Can olanzapine affect fertility?

Like clozapine, olanzapine has minimal effects on prolactin levels. These cases indicate that after switching from traditional neuroleptics to atypical agents, fertility may normalize and unplanned or even unwanted pregnancies may occur.

How long does olanzapine stay in your system?

How long does olanzapine stay in my body? Individuals break down medications at different rates. On average, it takes up to seven days for most of the olanzapine to be gone from the body. Before making any changes to your medication, talk with your health care provider about the benefits and risks.

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Does everyone gain weight on olanzapine?

The results of the study revealed that there is a significant gain in weight with olanzapine, which is related to age ≥40 years and sex; women ≥40 years of age are more prone to gain weight in comparison with those <40 years and men of any age group. The weight gain is not related to the dose of olanzapine and BMI.

Does olanzapine cross the placenta?

However, another study reported the rate of placental passage of olanzapine to be much lower (17%) [38]. Potential fetal exposure to olanzapine should be taken into consideration when weighing the benefits and risks of remaining on olanzapine therapy.

What does pregnancy category C mean?

Category C. “Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.”

What is the safest antidepressant for pregnancy?

Antidepressants that are considered safer include:

  • Fluoxetine (Prozac, Sarafem)
  • Citalopram (Celexa)
  • Sertraline (Zoloft)
  • Amitriptyline (Elavil)
  • Desipramine (Norpramin)
  • Nortriptyline (Pamelor)
  • Bupropion (Wellbutrin)

Do antipsychotics affect pregnancy?

To date, no definitive association has been found between use of antipsychotics during pregnancy and an increased risk of birth defects or other adverse outcomes.

Can you take anti anxiety meds while pregnant?

Generally, these antidepressants are an option during pregnancy: Certain selective serotonin reuptake inhibitors (SSRIs). SSRIs are generally considered an option during pregnancy, including citalopram (Celexa) and sertraline (Zoloft). Potential complications include maternal weight changes and premature birth.

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Can I take quetiapine while pregnant?

Taking quetiapine in pregnancy would not normally require extra monitoring of your baby. Weight gain and increased blood sugar (hyperglycaemia) can be side effects of quetiapine. If you are treated with quetiapine during pregnancy your doctor may suggest extra monitoring of your weight and blood sugar levels.

What medications to avoid while trying to conceive?

Prescription Medications

Some medications that are advised to avoid are acne medications, clotting medications, medications for hypertension, and medications for epilepsy. Additionally, it is advised that anti-inflammatory steroids are avoided unless otherwise specified by your physician.

Can olanzapine cause missed period?

This medication may increase a certain natural substance (prolactin) made by your body. For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant.

What are the contraindications of olanzapine?

Who should not take OLANZAPINE?

  • breast cancer.
  • diabetes.
  • a high prolactin level.
  • high cholesterol.
  • high amount of triglyceride in the blood.
  • excessive fat in the blood.
  • dehydration.
  • overweight.
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